This book aims to provide a comprehensive exploration of three critical processes involved in cell death and survival, each playing a unique role in cancer development, progression, and treatment. Autophagy, apoptosis, and ferroptosis are distinct yet interconnected pathways that regulate cellular homeostasis and response to stress. In the context of oncology, these processes are of paramount importance. Cancer cells often manipulate autophagy and apoptosis to their advantage, evading death and promoting survival even in the face of therapeutic interventions.
Understanding these mechanisms provides valuable insights into how cancer can be effectively targeted and treated. Furthermore, the emerging role of ferroptosis adds an exciting dimension to the ongoing quest for innovative cancer therapies. This book is structured to offer a detailed examination of each process, beginning with their fundamental biological mechanisms, followed by their implications in cancer biology.
The chapters are designed to guide the reader through the intricate interplay between autophagy, apoptosis, and ferroptosis, highlighting recent discoveries, ongoing research, and potential therapeutic applications.
Contents:
- Autophagy: Basics and Role in Pathological Diseases (Mehrdad Hashemi, Safa Tahmasebi, Pezhman Shafiei Asheghabadi, Amirhossein Mardi, Elaheh Mohandesi Khosroshahi, Bita Pakshad, Shima Hajimazdarany, Mohammad Eslami Vaghar, Koorosh Shahpasand, Najma Farahani, Noushin Nabavi, Afshin Taheriazam, Sima Orouei, Maliheh Entezari)
- Autophagy Mechanism in Cancer: Overall View and Recent Advances (Mehrdad Hashemi, Najma Farahani, Mahsa Mohammadzadeh, Amir Mohammad Bagheri, Kosar Salimy, Rasoul Raesi, Arman Tohidi, Saghar Gholami, Hanieh Hajizadeh, Roya Malek Mohammadi, Noushin Nabavi, Afshin Taheriazam, Sima Orouei, Maliheh Entezari)
- Autophagy in the Regulation of Cancer Proliferation (Mehrdad Hashemi, Safa Tahmasebi, Azarmidokht Aminazad, Amirhossein Mardi, Atena Sadat Hosseini, Najma Farahani, Ali Moghadas Jafari, Soolmaz Moradi, Fereshteh Atabi, Koorosh Shahpasand, Noushin Nabavi, Afshin Taheriazam, Sima Orouei, Maliheh Entezari)
- Autophagy in the Regulation of Cancer Metastasis (Mehrdad Hashemi, Najma Farahani, Ali Moghadas Jafari, Sara Karami, Zeynab Ashari, Sohaib Najafi, Mehrdad Bagheri Pozve, Negin Khazaee, Khorshid Abdali, Noushin Nabavi, Afshin Taheriazam, Sima Orouei, Maliheh Entezari)
- Autophagy in the Regulation of Drug Resistance (Mehrdad Hashemi, Payman Rahimzadeh, Mohammad Eslami Vaghar, Maryam Sahafi Bandary, Ali Moghadas Jafari, Reza Morovatshoar, Azarmidokht Aminazad, Neda Zali, Hanieh Motie Arani, Koorosh Shahpasand, Noushin Nabavi, Najma Farahani, Afshin Taheriazam, Sima Orouei, Maliheh Entezari)
- Autophagy in the Regulation of Radio-Resistance (Mehrdad Hashemi, Payman Rahimzadeh, Ali Moghadas Jafari, Leila Mohammadnahal, Neda Zali, Sam Saghari, Shima Hajimazdarany, Mahdieh Farid, Atousa Bidardel, Koorosh Shahpasand, Noushin Nabavi, Najma Farahani, Afshin Taheriazam, Sima Orouei, Maliheh Entezari)
- Non-Coding RNAs in the Regulation of Autophagy (Mehrdad Hashemi, Safa Tahmasebi, Saloomeh Khoushab, Najma Farahani, Amin Ghorbani, Mehrnaz Kalhor Chegini, Kimia Abraheh, Fatemeh Rezaei, Mahsa Taghipour Barogh, Arash Matinahmadi, Zoofa Zayani, Noushin Nabavi, Afshin Taheriazam, Sima Orouei, Maliheh Entezari)
- Autophagy and Cancer Stem Cells (Mehrdad Hashemi, Rasoul Raesi, Sana Taheri, Reza Morovatshoar, Vahid Tavakolpour, Samira Moradi, Mohammad Eslami Vaghar, Maryam Deldar Bayat, Fereshteh Atabi, Koorosh Shahpasand, Noushin Nabavi, Najma Farahani, Afshin Taheriazam, Sima Orouei, Maliheh Entezari)
- Nanoparticles in the Regulation of Autophagy for Cancer Therapy (Mehrdad Hashemi, Payman Rahimzadeh, Vahid Tavakolpour, Seyedeh Kimia Zomorrodian, Mohammad Eslami Vaghar, Saba Vazirbani Arasi, Fereshteh Atabi, Behdokht Jamali, Koorosh Shahpasand, Najma Farahani, Noushin Nabavi, Afshin Taheriazam, Sima Orouei, Maliheh Entezari)
- Apoptosis: Basics and Role in Pathological Diseases (Mehrdad Hashemi, Rasoul Raesi, Bita Pakshad, Asal Abolghasemi Fard, Fatemeh Naseri Atashani, Mobin Mirzaie, Fereshteh Atabi, Koorosh Shahpasand, Noushin Nabavi, Najma Farahani, Afshin Taheriazam, Sima Orouei, Maliheh Entezari)
- Apoptosis Mechanism in Cancer: Overview View and Recent Advances (Mehrdad Hashemi, Payman Rahimzadeh, Zeinab Khazaei Koohpar, Hosein Izadi, Amirsoheil Karami, Haniyeh Bakhtiari Beklar, Amirhossein Mahmoudjanlou, Fereshteh Atabi, Noushin Nabavi, Najma Farahani, Afshin Taheriazam, Sima Orouei, Maliheh Entezari)
- Apoptosis and Autophagy Interaction in Cancer (Mehrdad Hashemi, Raziehe Habibifard, Saba Asadi, Alireza Dadfar, Hamideh Moradi, Atena Sadat Hosseini, Armin Nikdehqan, Munes Ghorbanalinia, Noushin Nabavi, Najma Farahani, Afshin Taheriazam, Sima Orouei, Maliheh Entezari)
- Apoptosis and Cancer Drug Resistance (Mehrdad Hashemi, Reza Akhavan-Sigari, Azarmidokht Aminazad, Mahsa Ghandi, Reza Mohammadi, Anahita Bizhanpour, Arta Setayesh, Mitra Behroozaghdam, Noushin Nabavi, Najma Farahani, Afshin Taheriazam, Sima Orouei, Maliheh Entezari)
- Apoptosis and Cancer Radio-Resistance (Mehrdad Hashemi, Zeinab Safarpour Lima, Ali Moghadas Jafari, Nakisa Rezakhani, Mohammadfahim Rafati, Negin Soleimani, Mohammad Eslami Vaghar, Koorosh Shahpasand, Noushin Nabavi, Najma Farahani, Afshin Taheriazam, Sima Orouei, Maliheh Entezari)
- Non-Coding RNAs in the Regulation of Apoptosis in Cancer (Mehrdad Hashemi, Mina Tahernejad, Sadaf Gholami, Seyedeh Sepideh Aghamirli, Parham Moradi, Reza Morovatshoar, Maedeh Chalkosh Noori, Saba Abdi, Nahid Keramati, Mitra Behroozaghdam, Noushin Nabavi, Najma Farahani, Afshin Taheriazam, Sima Orouei, Maliheh Entezari)
- Natural Products in the Treatment of Cancer by Targeting Apoptosis (Mehrdad Hashemi, Mahmoud Dehghani-Ghorbi, Mohammad Eslami Vaghar, Haniyeh Bakhtiari Beklar, Nastaran Dehghani, Mitra Behroozaghdam, Behdokht Jamali, Koorosh Shahpasand, Noushin Nabavi, Najma Farahani, Afshin Taheriazam, Sima Orouei, Maliheh Entezari)
- Nanoparticles in the Stimulation of Apoptosis in Cancer Therapy (Mehrdad Hashemi, Mahsa Shahrashoob, Hiva Khombak, Abdolrahman Fasihi Nasab Parizi, Alireza Khosravinejad, Fatemeh Maleki, Bahar Zinali Sohanaki, Helia Adib, Noushin Nabavi, Najma Farahani, Afshin Taheriazam, Sima Orouei, Maliheh Entezari)
- Ferroptosis: Basics and Role in Pathological Diseases (Mehrdad Hashemi, Masoumeh Beheshti, Sina Etemadi Far, Mohammad Eslami Vaghar, Behdokht Jamali, Mitra Behroozaghdam, Koorosh Shahpasand, Noushin Nabavi, Najma Farahani, Afshin Taheriazam, Sima Orouei, Maliheh Entezari)
- Ferroptosis Mechanism in Cancer: An Overview of Resistance Mechanisms (Mehrdad Hashemi, Amirmohammad Khalifehsoltani, Saba Vazirbani Arasi, Sara Karami, Mohammad Eslami Vaghar, Mahdi Moassesfar, Mitra Behroozaghdam, Behdokht Jamali, Noushin Nabavi, Najma Farahani, Afshin Taheriazam, Sima Orouei, Maliheh Entezari)
- Ferroptosis and Autophagy Interactions in Cancer (Mehrdad Hashemi, Mansour Rajabivahid, Alireza Khosravinejad, Fatemeh Maleki, Behdokht Jamali, Mohammad Eslami Vaghar, Paniz Salami, Koorosh Shahpasand, Noushin Nabavi, Najma Farahani, Afshin Taheriazam, Sima Orouei, Maliheh Entezari)
- Ferroptosis and Cancer Drug Resistance (Mehrdad Hashemi, Najma Farahani, Mohammad Eslami Vaghar, Aran Moshiri, Rojia Ghasemimovaghar, Diana Dadkhah, Nakisa Rezakhani, Koorosh Shahpasand, Noushin Nabavi, Afshin Taheriazam, Sima Orouei, Maliheh Entezari)
- Ferroptosis and Cancer Radio-Resistance (Mehrdad Hashemi, Najma Farahani, Atieh Mirzaahmadi, Ali Moghadas Jafari, Mohammad Eslami Vaghar, Atousa Bidardel, Yeganeh Esfahaniolasl, Koorosh Shahpasand, Noushin Nabavi, Afshin Taheriazam, Sima Orouei, Maliheh Entezari)
- Non-Coding RNAs in the Regulation of Ferroptosis in Cancer (Mehrdad Hashemi, Payman Rahimzadeh, Anahita Bizhanpour, Mohammad Eslami Vaghar, Naghmeh Zhalehjoo, Golnaz Enayat, Delaram Jafari, Fatemeh Jafari, Koorosh Shahpasand, Noushin Nabavi, Najma Farahani, Afshin Taheriazam, Sima Orouei, Maliheh Entezari)
- Natural Products for Targeting Ferroptosis in Cancer Therapy (Mehrdad Hashemi, Behdokht Jamali, Mahmoud Dehghani-Ghorbi, Mohammad Eslami Vaghar, Maryam Hasanzade Moghadam, Sara Bagheri, Mahsa Mirzayi, Koorosh Shahpasand, Noushin Nabavi, Najma Farahani, Rasoul Raesi, Afshin Taheriazam, Sima Orouei, Maliheh Entezari)
- Nanoparticles in the Stimulation of Ferroptosis in Cancer Therapy (Mehrdad Hashemi, Rasoul Raesi, Mohammad Eslami Vaghar, Solmaz Hamzeh Jouneghani, Saina Hasany, Seyed Hesamoddin Bidooki, Maryam Mirzaei, Koorosh Shahpasand, Noushin Nabavi, Najma Farahani, Afshin Taheriazam, Sima Orouei, Maliheh Entezari)
Readership: Primary audience: Researchers, Medical doctors, Pharmacists, Biologists. Secondary audience: Oncologists, Molecular biologists.
