Thermodynamics for Drug Product Design

Comprehensive reference reviewing how thermodynamic principles underpin the design of drug products and their applications

Written in an easy-to-read and understand style, Thermodynamics for Drug Product Design offers an abundance of real-life drug product design examples, applications, personal anecdotes, and solved problems that contextualize thermodynamic principles for the drug product design scientist. Advanced undergraduate and beginning graduate students will learn to apply thermodynamic principles to create robust drug products and to predict, prevent, analyze, and evaluate the root cause of product failures. Professionals engaged in drug product design will find this book to be a rich and easy to use reference guide.

The first two chapters address some key basics of data reporting and analysis, math, and thermodynamic properties using simple and accessible language. These chapters also help readers understand fundamental underlying definitions and physical relationships required to use thermodynamic laws in the design of drug products. In later chapters, the book focuses on six industrial pharmacy relevant thermodynamic topics: the laws of thermodynamics, Gibbs free energy, equilibrium, drug solubility equilibrium, surface thermodynamics, and adsorption phenomena.

Thermodynamics for Drug Product Design features chapters including:

• Data Reporting and Analysis
• Underlying Thermodynamic Physical Property Relationships and Definitions
• The Laws of Thermodynamics
• Gibbs Free Energy
• Equilibrium
• Drug Solubility Equilibrium
• Surface Thermodynamics
• Adsorption Phenomena

What others say:

“…comprehensive, rigorous, and logically organized …the explanations flow effortlessly from the page…”
—BRUNO HANCOCK, PhD, FAAPS, Editor, JPharmSci

“…has a unique style of communicating complex scientific issues…”
—KEN MORRIS, PhD, FAAPS, Professor Emeritus, Founding Director Lachman Institute

“…unusual wide range of subjects…unusual for detail…”
—DALE ERIC WURSTER, PhD, FAAPS, Professor Emeritus, 2019 AAPS President