- 1471 new definitions, 5,236 revised or updated definitions, a new Chemical Abstract Number index, and an update of all trademarks
- Significant expansion of both chemical and biochemical terms including the addition of biochemical terms in the emerging fields in biology and biological engineering such as synthetic biology, highlighting the merging of the sciences of chemistry and biology
- Updates and expands the extensive data on chemicals, trade name products, and chemistry-related definitions
- Adds entries for notable chemists and Nobel Prize winners, equipment and devices, natural forms and minerals, named reactions, and chemical processes
- Update on toxicological profiles
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