ORGANOIDS: ADVANCEMENTS IN DRUG DISCOVERY & PRECISION MED

This comprehensive book delves into the cutting-edge world of organoid technology, exploring its transformative impact in offering a more accurate and dynamic platform for studying diseases and developing therapies. It guides readers through the foundational science of organoid generation, then delves into their growing role in drug discovery — from screening potential compounds to modeling complex diseases with unprecedented precision. It emphasizes the promise of organoids in personalizing medicine, paving the way for major advancements in cancer therapy, neurological research, and the understanding of infectious diseases. The text also explores future-forward tools like gene editing, AI-driven diagnostics, and omics technologies that are poised to redefine the field. It is an invaluable resource for researchers, clinicians, and industry professionals dedicated to exploring the frontiers of organoid technology and its applications in modern medicine.

Contents:

• Foreword
• About the Editors
• Mastering Organoids: Fundamentals of Generation and Cultivation (Huayang Xing, Suyao Xie, Yidan Chen, Jing Yue, Mohan Wu, Yang Wu)
• Advanced Organoid Culture Systems (Yueyue Huangfu, Dengfeng Zhang, Jiaming Ye, Mingliang You, and Bingcheng Lin)
• Automation in Organoid-Based Precision Medicine (Yanan Shi, Quanlin Xin, Wei Kang)
• Organoid Engineering Techniques for Drug Discovery and Development (George Michael Nicolas, Ut Fai Chao, Shaohua Ma)
• Organoid-Driven Drug Discovery: Precision Screening and Target Validation (Yunqi Man, Yanfei Liu, Qiwen Chen, Zhenbao Liu)
• Perspectives from a High-throughput Screening and Target Identification Laboratory (Valentina Gonzalez-Pecchi, Elizabeth L Zoeller, Matías I Hepp, Sebastián Vera, Xiulei Mo, Kecheng Lei, Yuhong Du)
• Patient-Derived Organoids and Personalized Medicine (Xiaoxiao Wang, Yufei Wang, Le Cheng, Zhaowu Ma, Xiaoguang Chen, Louis Zizhao Wang)
• Optimizing Organoid-Based Drug Sensitivity Testing: Essential Insights and Best Practices (Yi Zhou, Ling Jiao, Wentao Yang, Xiaozhen Liu)
• Single-Cell Analysis and Omics Techniques (Long Chen, Wei Jin, Xinrui Zhang, Jun Zhang, Liming Chen)
• Artificial Intelligence and Machine Learning in Organoid Technology (Hong Kai Lee, Min Qiu, Yijun Chen)
• Ethical and Regulatory Considerations (Khatri Simran, Win Lwin Thuya, Cao Yang, Yifeng Ren, Malia Alexandra Foo, Fengming You)
• Index

Readership: Faculty, researchers and graduate students in the fields of tissue engineering and regenerative medicine, bioengineering, stem cells, pharmacology and drug discovery, precision medicine, disease modelling, cellular biology.