Long-lived Proteins in Human Aging and Disease

Long-lived Proteins in Human Aging and Disease

Auteur: Roger J. W. Truscott
Uitgever: Wiley
Editie: 1
Publicatiedatum: 2021
ISBN: 9783527347285

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This authoritative overview on an emerging topic in the molecular life sciences covers all aspects of the aging of (long-lived) proteins. It describes the molecular mechanisms of aging on the protein level, in particular the most common side chain modifications and includes analytical methods to study protein half-life and the accumulation of modifications. Finally, the impact of protein aging on several age-related disases in humans is dissected, and their role in limiting human lifespan is discussed.

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