Phosphodiesterases and Their Inhibitors

Phosphodiesterases and Their Inhibitors

Auteur: Raimund Mannhold, Hugo Kubinyi, Gerd Folkers, Spiros Liras, Andrew S. Bell
Uitgever: Wiley
Editie: 1
Publicatiedatum: 2014
ISBN: 9783527332199

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Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug.
Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE targets and their inhibitors. Drug development options for all major human PDE families are discussed and cover diverse therapeutic fields, such as neurological/psychiatric, cardiovascular/metabolic, pain, and allergy/respiratory diseases. Finally, emerging chemotherapeutic applications of PDE inhibitors against malaria and other tropical diseases are discussed.

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