Alzheimer’s DiseaseÉdition 1

Alzheimer’s disease continues to present one of the foremost scientific and clinical challenges in contemporary neuroscience. Despite significant advances in molecular biology and neuroimaging, its complex etiology and progressive course remain only partially understood, and truly effective disease-modifying therapies remain elusive.

This scholarly volume offers a comprehensive and integrative examination of Alzheimer’s disease, combining cutting-edge research with clinical perspectives. Alzheimer’s Disease: Diagnosis, Molecular Targets, and Therapeutic Modalities assembles contributions from leading experts, providing in-depth analysis across a wide range of critical topics:

• Innovative diagnostic biomarkers for early detection, prognosis, and therapeutic monitoring
• Exploration of molecular targets, including secretases, SIRT2, RAGE, calpain, caspases, NMDA receptors, and others implicated in AD pathophysiology
• Emerging therapeutic interventions encompassing enzyme inhibitors, immunotherapeutic strategies, metal chelation, neurotrophic modulation, and aggregation inhibitors
• Advances in translational research featuring nanotechnology-based delivery systems and bioactive natural compounds
• Evidence-based lifestyle interventions integrating nutrition and physical activity in disease management

Spanning 21 rigorously curated chapters, this volume offers a multidisciplinary framework that bridges fundamental research, translational applications, and clinical relevance. It is an essential reference for neuroscientists, clinical researchers, pharmacologists, graduate students, and healthcare professionals engaged in the investigation and management of neurodegenerative disorders.

By synthesizing current scientific knowledge with emerging therapeutic strategies, this volume aims to advance understanding and stimulate further research toward effective interventions for Alzheimer’s disease.