Antes de Memmo, mis apuntes estaban dispersos en PDFs. Ahora, un espacio de trabajo lo reúne todo y veo exactamente lo que me queda por estudiar.
Strychnine’s poisonous nature was known in 16th century Europe, and the alkaloid was isolated in pure form for the first time in 1818. Then began a more than century-long quest to unravel the structure of strychnine that led to two Nobel prizes, clearly without the assistance of the modern spectroscopic methods to which we now have access. In his 1963 report of the synthesis, Woodward said, "The tangled skein of atoms which constitutes its molecule provided a fascinating structural problem that was pursued intensively during the century just past, and was solved finally only within the last decade." The structure elucidation of complex natural products is facilitated today by access to modern instrumentation and experimental techniques. Using a modern 600 MHz NMR spectrometer equipped with a 1.7 mm cryogenic probe and a 1 mg sample, it is now possible to acquire a comprehensive suite of 2D NMR spectra that rigorously characterizes the complex structure of strychnine in a scant 24 hours. When the 2D NMR data are combined with Computer-Assisted Structure Elucidation methods, the structure can be solved in mere seconds. It is against this historical backdrop that these two volumes regarding the Structure Elucidation of Natural Products by NMR is set.
Volume 1 discusses contemporary NMR approaches including optimized and future hardware and experimental approaches to obtain both the highest quality and most appropriate spectral data for analysis. Volume 2 considers data processing and algorithmic based analyses tailored to natural product structure elucidation and reviews the application of NMR to the analysis of a series of different natural product families including marine natural products, terpenes, steroids, and carbohydrates. These books, bringing together acknowledged experts, uniquely focus on the combination of experimental approaches and modern hardware and software applied to the structure elucidation of natural products. The volumes will be an essential resource for NMR spectroscopists, natural product chemists and industrial researchers working on natural product analysis or the characterization of impurities and degradation products of pharmaceuticals that can be scarce as natural product samples.
Antes de Memmo, mis apuntes estaban dispersos en PDFs. Ahora, un espacio de trabajo lo reúne todo y veo exactamente lo que me queda por estudiar.
Los resúmenes de Memmo son oro antes de los exámenes. No tengo que releer 800 páginas dos semanas antes, solo las partes importantes.
El chat de IA me ha salvado la noche antes de un examen más de una vez. Sigo preguntando hasta que lo entiendo, sin esperar a que un grupo de estudio responda.
Los cuestionarios aciertan exactamente lo que necesito saber. Memmo registra dónde me atasco, así que solo practico lo que vale la pena.
Las flashcards con repetición espaciada son magia. Memmo sabe cuándo estoy a punto de olvidar algo y me lo recuerda.
Los pódcasts de IA son mis favoritos. Los escucho de camino a la universidad y obtengo un resumen sin tener que sentarme frente a un ordenador.
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